Functioning as a barrier against external threats, the skin is part of the immune system. It is equipped with immune cells contributing to battle potential intruders. Receding in the upper skin layer, the epidermis, is an immune cell called Langerhans cell (Lc). This cell is key to the skins immunity due to its strategic position, functioning as a supervisor of immune responses. Lc is equipped with highly specialized receptors that bind to specific pathogen-associated molecular pattern molecules. Beta-1,3/1,6-glucan from baker’s yeast is an example of such a molecule. It is an immunostimulator, which makes Lc “alert” upon binding. This contributes to maintain an optimal skin barrier containing efficient immune cells to battle daily threats deteriorating the skin such as; pathogen attacks, UV-rays, smoke, chemicals, pollution, unhealthy diets, lack of sleep and stress. Topical application of beta-1,3/1,6-glucan from baker’s yeast has shown promising results to target negative effects of daily threats. Daily threats may lead to premature ageing, inflammation, age spots and wrinkles, as well as problematic skin conditions. By favoring the optimal resources of the skins defense army, cosmetic products with beta-1,3/1,6-glucan from baker’s yeast is a complimentary strategy contributing to maintain steady state that results in a healthy skin. Here, we describe the current understanding of the mode of action of beta-1,3/1,6-glucan on the skin immunity when applied topically.
The ability of the human body to quickly recognise and eradicate invading pathogens is essential for controlling infections and preventing infectious disease. Nature has therefore armed the body with a highly efficient defence apparatus: the immune system. The immune system normally has the upper hand on opportunistic microorganisms; thanks mainly to the evolutionary conserved innate immune defence which fights back more than 99 % of all the microbial threats the body is exposed to every day. Beta-1,3/1,6- glucan from baker’s yeast (Saccharomyces cerevisiae) is a biological response modifier which through direct interaction with cells of the innate immune system, safely primes the immune system to respond quickly and adequately to infectious challenge. This feature has, over the last 20 years, made beta-1,3/1,6-glucan from baker’s yeast attractive as a dietary supplement and as a functional food ingredient. Here, we explain the current understanding of the mode of action of beta-1,3/1,6-glucan on the immune system.
Awakening the Skin’s Immunity. Beta-1,3/1,6-Glucan from Baker’s Yeast, an Active Skincare Ingredient
The skin’s immune system plays a key role in the healthy functioning of the skin. Immune cells located in the skin tissue act as soldiers, constantly preventing the invasion of harmful microorganisms and helping to maintain the skin homeostasis (stability). These cells are essential for the constant repair, protection and renewal of the skin. Thus, efficient skin immunity is essential for healthy and beautiful skin. The skin’s immunity is constantly challenged by factors such as pollution, sunlight and stress, which deteriorate the skin’s quality. In addition, the concentration of immune cells decreases as we age, and their efficiency declines. This translates into typical signs of ageing such as wrinkles, fines line and age spots. Reduced skin immunity can also result in inefficient wound healing and inflammation, having a negative impact on the overall health. Beta-1,3/1,6-glucan is an immune-enhancing component extracted from baker’s yeast that interacts with Langerhans cells, a key orchestrator of immune responses in the skin. In this paper, we review the effects of the topical application of beta-1,3/1,6-glucan on the skin’s immunity, and discuss its potential as a skincare ingredient.
Modern life is full of frustrations, deadlines and demands. Many people put themselves under stress so routinely that it has become a way of life. While short-term stress seems to enhance immune function temporarily, long-term stress suppresses and dysregulates the immune system, making it less fit to fight off infections. Consumers typically equate immune support with the cold/flu season, and many dietary supplement brands follow suit. In this paper, we make the case for immune support supplementation as a tool for stress management, and present yeast beta-glucan as an ideal ingredient for immune support formulas. Yeast beta-1,3/1,6-glucan from baker’s yeast (Saccharomyces cerevisiae) is a naturally-derived, bioactive component that can help improve immune function of people subject to long-term stress.
Increasing Product Value With Yeast Beta-1,3/1,6-Glucan – How to Compete in the Sports Nutrition Sector
Athletes and people with active lifestyles often experience respiratory tract symptoms (RTS), and many struggle with recurring upper respiratory tract infections (URTIs), which can result in disrupted training schedules and poor physical performance. Beta-glucan from baker's yeast can be used in sports nutrition products to support healthy immune function and keep performance at peak levels. - A well-functioning immune system is crucial for athletic performance. - Research shows physical activity can impact immune function and increase susceptibility of RTS. - Beta-glucan from baker’s yeast can support immune health of athletes during periods of intensive training.